Check this out:
view linkThe wife's S&W LadySmith (.38/.357 magnum) is at 11:00.
She likes the size and simplicity of a revolver. She also thinks her gun is "pretty".
At 12:00 is my Colt Mustang (.380 Auto) which is a small semi-automatic pistol that I carry on occasion. My "goin' to the store" gun, although the way things are going now days, I carry one of my .45s to the store. .380 Auto is about as small a caliber as I think you should use for self defense.
At 4:00 is a Kimber Ultra CDP (.45 ACP), fits nicely in my pocket with a pocket holster, which is a pretty good caliber for personal defense, but has a bit of a kick to it. At 3:00 is the other .45 I carry, a S/A XD45. Fairly big, but I'm a big guy so it carries pretty well.
The one at 2:00 is a 9mm Beretta 92FS. That's the one I keep in my home office desk. I have laser grips on this one, more because I like gadgets. I really doubt I would be able to use them in a critical situation, requires operating a small switch and push button. Your fine motor skills go away in that kind of situation, so I wouldn't count on them.
The one in the center is a Ruger GP100 (.38/.357 magnum) same as the wife's LadySmith, so she uses this as her home office desk gun.
The one with the scope is a Ruger Super Redhawk (.44 magnum). A bit much to carry except in bear country.
Probably the most critical piece of hardware for self defense is the nut that is holding the gun, so make sure you get good training and practice.
In case you are wondering, we don't have any grandkids yet, so I just love talking about my guns.